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Mazdutide is a dual  agonist  of the GLP-1receptor and glucagon receptor. It is an analog of oxyntomodulin (OXM). 

The drug is developed by Eli Lilly and is currently in multiple Phase III studies.

 In May 2025, a result of Phase III study has shown that once-weekly mazdutide led to clinically relevant reductions in body weight in Chinese adults with overweight or obesity.